Fisetin Function:

1. Anti-aging

(1) Senolytics effects of Fisetin on healthy aging

The scientific theory, established in all the top journals like Nature, Cell and Science, is that those senescent cells are the root of all evil, and cause all possible diseases , aging, alzheimer’s, arthritis, diabetes, cancer even. Senolytic, on the other hand, clearing away dysfunctional senescent cells and allowing healthy cells to thrive.

Research has found that fisetin is an exceptionally powerful senolytic. A panel of flavonoid polyphenols was screened for senolytic activity. Fisetin is the most potent senoytic of the 11 tested compounds including Resveratrol and Quercetin. Fisetin was the most effective at removing senescent cells, both in cell culture and in mice.

(2) Fisetin for healthy aging, more than senolytics

Besides the senolytic effect, Fisetin acts on multiple anti-aging mechanisms to achieve health aging. Fisetin can achieve anti-aging through various mechanisms, including activating sirtuins, inhibiting mTOR pathway, and maintaining the GSH level. All these factors collectively contribute to the health aging benefits of fisetin.

2. Improves neurohealth

Fisetin possesses neurotrophic activity, promoting nerve cell differentiation. Neurotrophic factors are important for supporting the differentiation, survival, and functional maintenance of nerve cells.

(1) Cognitive supporting:

Oral administration of fisetin was shown to enhance learning and memory. The performance of old mice fed with fisetin is almost as good as young mice in object recognition and navigating a maze.

(2) Anti-depression supporting:

Fisetin has an anti-depression effect that can inhibit the enzyme which metabolizes serotonin. Fisetin also appeared to modulate the neuronal system which is responsible for the synthesis, storage, and release of the norepinephrine neurotransmitter. Low levels of norepinephrine can cause depression.

(3) Treatment of stroke supporting:

Fisetin has a stroke protective effect and even after the initial ischemic insult it still provides a significant level of protection. A study on rabbits proves that fisetin significantly reduced stroke-induced behavioral deficits.

(4) Preventing Alzheimer's disease:

A fisetin-supplemented diet showed clear improvements in both cognitive, psychiatry, and neurology behavior and could be useful for the treatment of AD.

3. Promotes Hair growth

One research found that fisetin blocks the anti-hair growth effects of dihydrotestosterone-the most potent hormone among the androgens. Fisetin promotes hair growth by the same mechanism of action as Dutasteride, a drug already approved for the treatment of prostate enlargement and can help to prevent and slow down hair loss. Subsequently, fisetin is a strong human telomerase reverse transcriptase (hTERT) augmenting compound and promotes hair growth of shaved skin in a study.

4. More Health Benefits of Fisetin

(1) Improves Bone Health

Fisetin promotes osteoblast differentiation and osteogenesis through GSK-3β phosphorylation at Ser9 and consequent β-catenin activation and could be used as an effective strategy to prevent bone resorption, inhibiting osteoporosis.

(2) Ameliorates pulmonary fibrosis

Studies have shown that fisetin also has beneficial effects on cardiovascular disease. On the one hand, fisetin can directly act on vascular smooth muscle cells in vivo to prevent hypertension caused by abnormal contraction of blood vessels. On the other hand, fisetin effectively alleviates myocardial ischemia-reperfusion injury by delaying clotting time, maintaining mitochondrial function and reducing oxidative stress.

(3) Weight control

Fisetin activities may help with weight control by increasing activity of AMPK (an enzyme involved in cellular metabolism) and inhabiting mTOR activit.